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CBX2 identified as driver of anoikis escape and dissemination in …

2018/11/26· f Relative intensity of CBX2 in benign human ovarian surface epithelium (HOSE, n = 10) compared to HGSOC, n = 53 (GSE18521; t-test p < 0.0001, F test p < 0.0001).

Two States of Myeloma Stem Cells - Clinical Lymphoma, Myeloma …

The identity of so-called malignant stem cells in multiple myeloma has long been controversial. However, it is now appreciated that a small population of myeloma cells has a stem-like capacity for self-renewal and resides within the population of recognizable myeloma plasma cells, although whether these cells are quiescent or proliferative remains unresolved. It is also now accepted that

Down-regulation of X-linked Inhibitor of Apoptosis Protein …

In this context, we have recently observed that down-regulation of Xiap by adenoviral antisense expression not only induced apoptosis in chemoresistant hOSE cancer cells (C13) in vitro, but also

Maintenance of Leukemia-Initiating Cells Is Regulated by the CDK …

2014/12/19· Often, leukemia initiating cells are chemoresistant due to their infrequent divisions, which appears to prevent their efficient eradiion , . Remarkably, it has been investigated that cell cycle restriction due to p21 CIP1 expression in LSCs is necessary to induce and maintain PML-RARα- or AML1-ETO-driven leukemogenesis in mice [14] .

Ginger inhibits cell growth and modulates angiogenic factors in …

2007/12/20· Ginger treatment resulted in similar effects in all cell lines tested, including the chemoresistant cell lines SKOV3 and ES-2[] (Figure 1B,C, p < .05 for all doses and time points). Untransformed human ovarian surface epithelial cells (HOSE) were minimally affected by ginger extract exposure at days 1 and 3, and showed some inhibition in growth by day 5 (Figure 1D , p > .05 for …

Two States of Myeloma Stem Cells - Clinical Lymphoma, …

The identity of so-called malignant stem cells in multiple myeloma has long been controversial. However, it is now appreciated that a small population of myeloma cells has a stem-like capacity for self-renewal and resides within the population of recognizable myeloma

Two States of Myeloma Stem Cells - Clinical Lymphoma, …

The identity of so-called malignant stem cells in multiple myeloma has long been controversial. However, it is now appreciated that a small population of myeloma cells has a stem-like capacity for self-renewal and resides within the population of recognizable myeloma

Resveratrol and P-glycoprotein Inhibitors Enhance the Anti-Skin Cancer Effects of Ursolic Acid | Molecular Cancer …

In addition, the Ca3/7 cells are also chemoresistant to doxorubicin hydrochloride, a P-gp substrate chemotherapeutic, relative to MT1/2 cell lines (). Doxorubicin hydrochloride reduced viability of MT1/2 cells with an IC 50 of 0.95 ± 0.29 versus an IC 50 of 45.2 ± 3P

Silencing of BAG3 promotes the sensitivity of ovarian cancer cells …

2017/6/6· BAG3, BCL2-associated athanogene 3; HOSE, human ovarian surface epithelial. BAG3 negatively regulates cisplatin-induced apoptosis in ovarian cancer cells To clarify the role of BAG3 in the regulation of sensitivity followed by chemotherapy, we transfected shRNA targeting BAG3 into SKOV3 and HO8910 cells.

Frontiers | CHTOP in Chemoresistant Epithelial Ovarian Cancer: …

2019/6/27· Objective: Chemoresistance is a major challenge in epithelial ovarian cancer (EOC) treatment. Chromatin target of protein arginine methyltransferase (CHTOP) was identified as a potential biomarker in chemoresistant EOC cell lines using label-free LC-MS/MS quantitative proteomics. Thus, the aim of this study is to investigate the role of CHTOP in chemoresistant …

Malignant Ascites in Ovarian Cancer: Cellular, Acellular, and …

2021/8/26· A human OSE cell line (HOSE) and four ovarian cancer cell lines (HEY, PEO.36, OVCA433, and OVHS-1) were examined for their response to the presence of ascites. Among the integrin subunits that were evaluated, only α 6 expression was significantly increased in response to ascites in all the cell lines, except HOSE.

Secretoglobin expression in ovarian carcinoma: lipophilin B gene …

2013/7/2· HOSE were cultured from normal ovaries of patients undergoing hysterectomy and bilateral salpingo-oophorectomy for benign pathologies, as previously reported [] and only cell cultures containing at least 99% epithelial cells were retained for total RNA extraction.

Ginger inhibits cell growth and modulates angiogenic factors in …

2007/12/20· Ginger treatment resulted in similar effects in all cell lines tested, including the chemoresistant cell lines SKOV3 and ES-2[] (Figure 1B,C, p < .05 for all doses and time points). Untransformed human ovarian surface epithelial cells (HOSE) were minimally affected by ginger extract exposure at days 1 and 3, and showed some inhibition in growth by day 5 (Figure 1D , p > .05 for …

Secretoglobin expression in ovarian carcinoma: lipophilin B gene …

2013/7/2· HOSE were cultured from normal ovaries of patients undergoing hysterectomy and bilateral salpingo-oophorectomy for benign pathologies, as previously reported [] and only cell cultures containing at least 99% epithelial cells were retained for total RNA extraction.

Maintenance of Leukemia-Initiating Cells Is Regulated by the CDK …

2014/12/19· Often, leukemia initiating cells are chemoresistant due to their infrequent divisions, which appears to prevent their efficient eradiion , . Remarkably, it has been investigated that cell cycle restriction due to p21 CIP1 expression in LSCs is necessary to induce and maintain PML-RARα- or AML1-ETO-driven leukemogenesis in mice [14] .

Chemotherapy Dosing Schedule Influences Drug Resistance …

Drug resistance leads to chemotherapy failure and is responsible for the death of a great majority of patients with metastatic, late-stage ovarian cancer. The present study addressed whether changes in the chemotherapy dosing schedule affect the development, further worsening, or circumvention of drug resistance in chemosensitive and chemoresistant ovarian cancer. Severe coined

Two States of Myeloma Stem Cells - Clinical Lymphoma, …

The identity of so-called malignant stem cells in multiple myeloma has long been controversial. However, it is now appreciated that a small population of myeloma cells has a stem-like capacity for self-renewal and resides within the population of recognizable myeloma

Multiple mechanisms underlying acquired resistance to taxanes in selected docetaxel-resistant MCF-7 breast cancer cells | BMC Cancer …

2014/1/22· Background Chemoresistance is a major factor involved in a poor response and reduced overall survival in patients with advanced breast cancer. Although extensive studies have been carried out to understand the mechanisms of chemoresistance, many questions remain unanswered. Methods In this research, we used two isogenic MCF-7 breast cancer cell lines selected for resistance to …

Ovarian Cancer | CancerIndex

The human ovarian cancer cell lines A-2780, A-2780CYP1A1(-) and non-cancerous human ovarian surface epithelial (HOSE) cells were employed in the present study. In contrary to other authors'' suggestions we have found that CYP1A1 is the major enzyme of CYP1 family involved in the metabolic activation of DMU-212.

Silencing of BAG3 promotes the sensitivity of ovarian cancer cells …

2017/6/6· BAG3, BCL2-associated athanogene 3; HOSE, human ovarian surface epithelial. BAG3 negatively regulates cisplatin-induced apoptosis in ovarian cancer cells To clarify the role of BAG3 in the regulation of sensitivity followed by chemotherapy, we transfected shRNA targeting BAG3 into SKOV3 and HO8910 cells.

Multifunctional APJ Pathway Promotes Ovarian Cancer …

surface epithelialcells (HOSE), OVCAR-4, and TykNu werea kind gift from Dr. Danny Dhanasekaran [University of Oklahoma Health Sciences Center (OUHSC), Oklahoma City, OK]. SKOV-3 and OVCAR-3 were a generous gift from Dr. Youngjae You profiling to

Structure–activity relationships of hydroxamate-based histone …

2017/11/28· 58 Monks A, Hose CD, Pezzoli P et al. Gene expression-signature of belinostat in cell lines is specific for histone deacetylase inhibitor treatment, with a corresponding signature in xenografts. Anticancer Drugs 20, 682–692 (2009).Crossref, Medline, CAS,

iASPP and Chemoresistance in Ovarian Cancers: Effects on …

Abstract Purpose: iASPP is a specific regulator of p53-mediated apoptosis. Herein, we provided the first report on the expression profile of iASPP in ovarian epithelial tumor and its effect on paclitaxel chemosensitivity. Experimental Design: Expression and amplifiion status of iASPP was examined in 203 clinical samples and 17 cell lines using immunohistochemistry, quantitative real-time

Malignant Ascites in Ovarian Cancer: Cellular, Acellular, and …

2021/8/26· A human OSE cell line (HOSE) and four ovarian cancer cell lines (HEY, PEO.36, OVCA433, and OVHS-1) were examined for their response to the presence of ascites. Among the integrin subunits that were evaluated, only α 6 expression was significantly increased in response to ascites in all the cell lines, except HOSE.

Frontiers | CHTOP in Chemoresistant Epithelial Ovarian Cancer: …

2019/6/27· Objective: Chemoresistance is a major challenge in epithelial ovarian cancer (EOC) treatment. Chromatin target of protein arginine methyltransferase (CHTOP) was identified as a potential biomarker in chemoresistant EOC cell lines using label-free LC-MS/MS quantitative proteomics. Thus, the aim of this study is to investigate the role of CHTOP in chemoresistant …

Frontiers | CHTOP in Chemoresistant Epithelial Ovarian Cancer: …

2019/6/27· Objective: Chemoresistance is a major challenge in epithelial ovarian cancer (EOC) treatment. Chromatin target of protein arginine methyltransferase (CHTOP) was identified as a potential biomarker in chemoresistant EOC cell lines using label-free LC-MS/MS quantitative proteomics. Thus, the aim of this study is to investigate the role of CHTOP in chemoresistant …

Secretoglobin expression in ovarian carcinoma: lipophilin B gene …

2013/7/2· HOSE were cultured from normal ovaries of patients undergoing hysterectomy and bilateral salpingo-oophorectomy for benign pathologies, as previously reported [] and only cell cultures containing at least 99% epithelial cells were retained for total RNA extraction.

Down-Regulation of X-linked Inhibitor of Apoptosis Protein …

antisense Xiap-induced apoptosis in the chemoresistant hOSE cancer cells was associated with caspase-3-mediated MDM2 cleavage and increased p53 content. These findings suggested that Xiap is not only regulating down-stream events of caspase-3, but

Ovarian Cancer | CancerIndex

The human ovarian cancer cell lines A-2780, A-2780CYP1A1(-) and non-cancerous human ovarian surface epithelial (HOSE) cells were employed in the present study. In contrary to other authors'' suggestions we have found that CYP1A1 is the major enzyme of CYP1 family involved in the metabolic activation of DMU-212.

CBX2 identified as driver of anoikis escape and dissemination in …

2018/11/26· f Relative intensity of CBX2 in benign human ovarian surface epithelium (HOSE, n = 10) compared to HGSOC, n = 53 (GSE18521; t-test p < 0.0001, F test p < 0.0001).